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Growth stimulation: Anabolic steroids were used heavily by pediatric endocrinologists for children with growth failure from the 1960s through the 1980s. Growth factors were also injected via subcutaneous cannula to increase muscle mass. Growth hormone (GH) was also injected to increase muscle mass and strength. It was used as well to stimulate growth and skeletal growth because it is a GH receptor agonist with an unknown mechanism and is generally thought to stimulate IGF-1 and IGF-1 receptors. This growth hormone (GH) has also been thought to increase the immune system and to reduce the incidence of cancers.Several studies have investigated the efficacy of growth hormone (GH), testosterone, and progesterone therapy on various forms of skeletal muscle wasting in patients with Duchenne muscular dystrophy (DMD) with high testosterone levels. Two of the studies examined the efficacy of these drugs and a third study included the progesterone-lutein solution for the treatment of DMD patients.When using growth hormone in patients with DMD, there appears to be a delay of the peak of growth after 12 weeks of therapy when compared to placebo but the increase in growth rate may be greater with testosterone than it was in DMD patients treated with placebo.Growth hormone (GH), testosterone (T), and progesterone are effective in treating children with DMD and are potentially helpful in alleviating muscular dystrophy. There appears to be a delay in the peak of growth with growth hormone (GH) therapy that can be alleviated with testosterone administration at doses that reach serum levels approximately 4-6µM (2ng/mL) while progesterone has a similar effect of a slight inhibition. The most common side effects in children with DMD using GH and T are dry scalp, dry hair growth (with a decrease in hair hair), headaches, decreased sex drive, and increased hair loss.It's possible that growth hormone and or progesterone may be more beneficial in DMD patients than in children not using steroids due to the possible delays in growth seen in that group, despite the reduced incidence of disease due to reduced fat mass and decreased rate of wasting. It's also possible that GH is better tolerated in patients that are younger, as more studies have examined the impact of younger age on treatment efficacy.3.2. Fat Mass and Muscle MassOne placebo-controlled study (n = 42) using testosterone (500-1,500mg), GH (200-2.5Similar articles: